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共收录 743 篇论文
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Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology单次给药、采用原子层沉积技术制备的热稳定型人乳头瘤病毒疫苗
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Brown Adipose Tissue and Its Role in Insulin and Glucose Homeostasis棕色脂肪组织及其在胰岛素与葡萄糖稳态中的作用
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鉴定小分子药物的靶蛋白对于理解药物的作用机理以及药物副作用至关重要。传统方法需要对药物进行化学修饰共价交联,可能会导致药物活性的改变。目前已经发展多种无需化学修饰便可以对药物靶蛋白鉴定的方法,包括药物亲和力反应靶标稳定性技术 (Drug affinity responsive target stability,DARTS)、蛋白质氧化速率稳定性技术 (Stability of proteins from rates of oxidation,SPROX)、细胞热移位分析...鉴定小分子药物的靶蛋白对于理解药物的作用机理以及药物副作用至关重要。传统方法需要对药物进行化学修饰共价交联,可能会导致药物活性的改变。目前已经发展多种无需化学修饰便可以对药物靶蛋白鉴定的方法,包括药物亲和力反应靶标稳定性技术 (Drug affinity responsive target stability,DARTS)、蛋白质氧化速率稳定性技术 (Stability of proteins from rates of oxidation,SPROX)、细胞热移位分析...
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[Identification techniques of small molecule drug target proteins without chemical modification and its applications: a review].[无化学修饰的小分子药物靶蛋白的识别技术及其应用:综述]
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Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder respiratory delivery.评估为干粉呼吸递送设计的喷雾干燥结核病疫苗候选物的稳定性
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Electrostatic spray drying for monoclonal antibody formulation.单克隆抗体制剂的静电喷雾干燥
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In Vitro Characterization of Inhalable Cationic Hybrid Nanoparticles as Potential Vaccine Carriers体外可吸入阳离子杂化纳米颗粒作为潜在疫苗载体的表征
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Chemical (neo)glycosylation of biological drugs.生物药物的化学(新)糖基化
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Development of mAb-loaded 3D-printed (FDM) implantable devices based on PLGA.基于PLGA的载单克隆抗体3D打印(FDM)植入装置开发
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First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody–Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors靶向蛋白酪氨酸激酶7的抗体-药物偶联物PF-06647020(Cofetuzumab Pelidotin)在晚期实体瘤中的首次人体研究
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Correlation between nasal mucosal temperature change and the perception of nasal patency: a literature review鼻黏膜温度变化与鼻通畅感知的相关性:文献综述
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Recent advances in microbial transglutaminase biosynthesis and its application in the food industry微生物谷氨酰胺转胺酶生物合成及其在食品工业中的最新研究进展
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Protein and Amino Acid Metabolism in Poultry during and after Heat Stress: A Review家禽热应激期间及之后的蛋白质与氨基酸代谢:综述
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Microparticle encapsulation of a tuberculosis subunit vaccine candidate containing a nanoemulsion adjuvant via spray drying.通过喷雾干燥将含有纳米乳剂佐剂的结核病亚单位疫苗候选物进行微粒包封
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Advances In Protein Chemistry And Structural Biology, Vol 121Advances In Protein Chemistry And Structural Biology, Vol 121
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Latest trends in structure based drug design with protein targets.基于结构的蛋白质靶点药物设计最新趋势
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Role of protein-protein interactions in allosteric drug design for DNA methyltransferases.蛋白质-蛋白质相互作用在DNA甲基转移酶的别构药物设计中的作用
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Protein-protein complexes as targets for drug discovery against infectious diseases.蛋白质-蛋白质复合物作为抗感染性疾病药物发现的靶点
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Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury泛素C端水解酶-L1和胶质纤维酸性蛋白作为串联生物标志物的全面综述——近期获美国食品药品监督管理局批准用于创伤性脑损伤患者颅内损伤评估
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Dietary Options for Rodents in the Study of Obesity研究肥胖的啮齿动物饮食选择