Protein-Based Drug Delivery in Brain Tumor Therapy.
基于蛋白质的药物递送在脑肿瘤治疗中的应用
📄 英文摘要 English Abstract
Despite the use of active surgeries, radiotherapy, and chemotherapy in clinical practice, brain tumors are still a difficult health problem due to their rapid development and poor prognosis. To treat brain tumors, various nanoparticles can be used to target effective physiological conditions based on continuously changing vascular characteristics and microenvironments to promote effective brain tumor-targeting drug delivery. In addition, a brain tumor-targeting drug delivery system that increases drug accumulation in the brain tumor area and reduces toxicity in the normal brain and peripheral tissues is needed. However, the blood-brain barrier is a big obstacle for drug delivery to the brain. In this chapter, we provide a broad overview of brain drug delivery and current strategies over the last few years. In addition, several questions have been reconsidered, such as whether nanoparticles believed to be delivered to the brain can pass through the blood-brain barrier, whether the drug is delivered to the target site, and what brain tumor treatment is possible.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
Despite the use of active surgeries, radiotherapy, and chemotherapy in clinical practice, brain tumors are still a difficult health problem due to their rapid development and poor prognosis. The blood-brain barrier is a big obstacle for drug delivery to the brain.
Methods:
N/A - Review article
Results:
Several questions have been reconsidered, such as whether nanoparticles believed to be delivered to the brain can pass through the blood-brain barrier, whether the drug is delivered to the target site, and what brain tumor treatment is possible.
Data Summary:
No quantitative results or key statistics are provided in the abstract.
Conclusions:
The chapter provides a broad overview of brain drug delivery and current strategies over the last few years, and reconsiders key questions regarding nanoparticle passage, drug targeting, and brain tumor treatment feasibility.
Practical Significance:
Various nanoparticles can be used to target effective physiological conditions based on continuously changing vascular characteristics and microenvironments to promote effective brain tumor-targeting drug delivery, and a brain tumor-targeting drug delivery system that increases drug accumulation in the brain tumor area and reduces toxicity in normal brain and peripheral tissues is needed.
📋 中文结构化总结 Chinese Structured Summary
背景:
尽管在临床实践中采用了积极的手术、放疗和化疗手段，脑肿瘤由于其快速发展和不良预后仍然是一个棘硬的公共卫生难题。血脑屏障是药物递送至大脑的一大障碍。
方法:
不适用——综述类文章
结果:
若干问题被重新审视，例如被认为可递送至大脑的纳米颗粒是否能够穿越血脑屏障，药物是否能够递送至靶点部位，以及脑肿瘤治疗的可行性如何。
数据摘要:
摘要中未提供定量结果或关键统计数据。
结论:
本章对近年来脑内药物递送及当前策略进行了广泛的综述，并就纳米颗粒穿越血脑屏障、药物靶向性以及脑肿瘤治疗可行性等关键问题进行了重新审视。
实际意义:
可利用多种纳米颗粒，基于不断变化的血管特征和微环境来靶向有效的生理条件，从而促进有效的脑肿瘤靶向药物递送；亟需建立一种能够增加药物在脑肿瘤区域蓄积并降低对正常脑组织及外周组织毒性的脑肿瘤靶向药物递送系统。