💊 药物制剂

Recent advances in identifying protein targets in drug discovery.

Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate.

Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes

Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology

鉴定小分子药物的靶蛋白对于理解药物的作用机理以及药物副作用至关重要。传统方法需要对药物进行化学修饰共价交联，可能会导致药物活性的改变。目前已经发展多种无需化学修饰便可以对药物靶蛋白鉴定的方法，包括药物亲和力反应靶标稳定性技术 (Drug affinity responsive target stability，DARTS)、蛋白质氧化速率稳定性技术 (Stability of proteins from rates of oxidation，SPROX)、细胞热移位分析...

[Identification techniques of small molecule drug target proteins without chemical modification and its applications: a review].

Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder respiratory delivery.

Electrostatic spray drying for monoclonal antibody formulation.

In Vitro Characterization of Inhalable Cationic Hybrid Nanoparticles as Potential Vaccine Carriers

Chemical (neo)glycosylation of biological drugs.

Development of mAb-loaded 3D-printed (FDM) implantable devices based on PLGA.

First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody–Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors

Microparticle encapsulation of a tuberculosis subunit vaccine candidate containing a nanoemulsion adjuvant via spray drying.

Latest trends in structure based drug design with protein targets.

Role of protein-protein interactions in allosteric drug design for DNA methyltransferases.

Protein-protein complexes as targets for drug discovery against infectious diseases.

Thorough overview of ubiquitin C‐terminal hydrolase‐L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury

Trop-2 protein as a therapeutic target: A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers

Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery