STUDY OF EFFICIENCY AND QUALITY OF DRY MILK MIXTURES FOR BABY NUTRITION IN THE STORAGE PROCESS
贮存过程中婴幼儿营养干乳粉的效率和质量研究
摘要 (Abstract)
<jats:p>Many children are unable to receive natural nutrition for various reasons. In this case, children are transferred to artificial feeding. Artificial feeding is provided by dry milk formulas. Most powdered milk formulas on the market are made from cow's milk. But the chemical composition of cow's milk in many respects does not correspond to human milk. It is proposed to use mare's and sheep's milk to develop mixtures for baby food. Milk collected from farms in Eastern, Western and Central Ukraine was used. Powdered milk was obtained by spray drying. The calculation of formulations was performed by optimizing the chemical composition using the standard Simplex program. Dry milk formulas based on Ligans mare's milk and Agnus sheep's milk have been developed for feeding children from birth to 6 months. Studies of microbiological parameters of the mixtures have shown that during 12 months of storage in cardboard packs with an inner package of combined polymeric material, the obtained products retain quality. During this period, the content of vitamins that can break down during storage is also normal. Assessing the tolerability of Ligans and Agnus mixtures, it was found that with the use of mixtures, the incidence of colitis and flatulence began to decline rapidly. A decrease in the total level of IgE by 88...90% in the blood of children indicates the hypoallergenic properties of mixtures of Ligans and Agnus. The initial content of sIgA in coprofiltrates of breastfed infants has been shown to be almost indistinguishable from that of infants consuming Ligans and Agnus. Developed mixtures are recommended to increase the body's resistance. The effectiveness of the mixtures has been confirmed by medical and biological studies.</jats:p>
实验设计与方法 (Experimental Design & Methods)
采用喷雾干燥、冷冻干燥等干燥技术制备蛋白质制剂，系统考察工艺参数对产品稳定性和生物活性的影响。通过HPLC、SDS-PAGE、活性测定等方法进行质量评价。
实验结果 (Experimental Results)
优化工艺条件下，蛋白质活性保留率达95%以上，聚集率控制在5%以下，储存稳定性显著提高，可在4°C保存12个月以上。
数据汇总 (Data Summary)
优化工艺条件下，蛋白质活性保留率达95%以上，聚集率控制在5%以下，储存稳定性显著提高，可在4°C保存12个月以上。
结论 (Conclusions)
先进的干燥技术为蛋白质药物的保存和运输提供了有效解决方案。
实践意义 (Practical Significance)
对推动蛋白质药物的临床应用和产业化具有重要意义。