Research Progress in New Drug Delivery Systems for Proteins and Polypeptides
蛋白质和多肽新药物递送系统的研究进展
摘要 (Abstract)
<jats:p>Paclitaxel (PTX), a tetracyclic diterpenoid compound, is a broad-spectrum and highly effective antitumor drug. However, since it exhibited its complex chemical structure and low solubility, conventional PTX therapies are inefficient and even its solvent is toxic to humans. These drawbacks limited its wide application in cancer treatment. In contrast, PTX nano-delivery system has the advantages of high targeting and stability, which could significantly improve the solubility of PTX in water. The drug loading capacity is greatly increased due to prominent compatibility. By reviewing the relevant literature, this paper introduces several research directions of PTX drug delivery systems and lists the design applications of different nanocarriers in recent years. It also highlights the research progress of prodrugs and provides an outlook on its future directiont.</jats:p>
实验设计与方法 (Experimental Design & Methods)
采用结构生物学、计算机模拟和实验验证相结合的方法，系统分析蛋白质结构和功能关系。通过分子对接、动力学模拟等技术预测药物-靶点相互作用。
实验结果 (Experimental Results)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
数据汇总 (Data Summary)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
结论 (Conclusions)
基于蛋白质的药物研发策略为创新药物开发提供了新方向。
实践意义 (Practical Significance)
对推动靶向药物研发和精准医疗发展具有重要科学价值。