Research Progressand Challenges of Anti-monkeypox Virus Drugs Targeting F13 Protein
靶向F13蛋白的抗猴痘病毒药物研究
📄 英文摘要 English Abstract
F13 protein is highly conserved in orthopoxviruses and serves as a classic broad-spectrum antiviral target. Nevertheless, clinical trials prove tecovirimat has weak efficacy and poor resistance profile. F13 inhibitors only hinder EEV ... Research progress on the role of protein tyrosine phosphatase receptor type R in cancer and its targeted drugs 受体型蛋白酪氨酸磷酸酶R在癌症中的作用及其靶向药物的研究进展 Chinese Bulletin Of Life Sciences Protein tyrosine phosphatase receptor type R (PTPRR), a key member of the protein tyro
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
F13 protein is highly conserved in orthopoxviruses and serves as a classic broad-spectrum antiviral target. Protein tyrosine phosphatase receptor type R (PTPRR) is also mentioned in relation to cancer and its targeted drugs.
Methods:
N/A - methodology details are not provided in the supplied text.
Results:
Clinical trials prove tecovirimat has weak efficacy and poor resistance profile. F13 inhibitors only hinder EEV.
Data Summary:
N/A - no quantitative results or key statistics are provided in the supplied text.
Conclusions:
N/A - no explicit conclusions are provided in the supplied text.
Practical Significance:
F13 protein serves as a classic broad-spectrum antiviral target, and PTPRR is associated with cancer and its targeted drugs.
📋 中文结构化总结 Chinese Structured Summary
背景:
F13蛋白在正痘病毒中高度保守，是经典的广谱抗病毒靶点。蛋白酪氨酸磷酸酶受体R型（PTPRR）也被提及与癌症及其靶向药物有关。
方法:
不适用——所供文本未提供方法学细节。
结果:
临床试验证明特考韦瑞疗效较弱且耐药谱不佳。F13抑制剂仅能抑制EEV。
数据摘要:
不适用——所供文本未提供定量结果或关键统计数据。
结论:
不适用——所供文本未提供明确结论。
实际意义:
F13蛋白是经典的广谱抗病毒靶点，PTPRR与癌症及其靶向药物相关。