A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
用于生物医学应用的钛及其合金的制造和特性的最新综述
摘要 (Abstract)
1. Acta Biomater. 2025 Sep 1;203:1-20. doi: 10.1016/j.actbio.2025.07.032. Epub 2025 Jul 12. Partially degradable Ti-Mg composites for biomedical applications: Recent advances and future perspectives. Li Z(1), Xu H(2), Cai X(3), Wang Y(4), He L(5), Yu G(6), Dong A(7). Author information: (1)Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science & Engineering, Shandong University, Jinan, 250061, PR China; Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China. (2)Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China; HuBei Engineering Institute, Huangshi, 435003, PR China. (3)Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, PR China. (4)Department of Breast Surgery, Jinan Maternity & Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250001, PR China. Electronic address: Beryuwang@126.com. (5)Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: helin_100@163.com. (6)School of Automotive Engineering, Changzhou Institute of Technology, Changzhou, 213032, PR China. (7)Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: apdong@sjtu.edu.cn. Given the low elastic modulus, favorable bioactivity, and intrinsic biodegradability of Mg alloys, Ti-Mg composites comprising Mg embedded within a continuous Ti matrix are considered a promising alternative to conventional porous Ti alloys. During implantation, the Mg phase undergoes programmable degradation-mediated pore-formation, which synergistically promotes osseointegration and bone infiltration, while the retained Ti matrix provides mechanical support similar to that of porous Ti alloy implants. This review provides a comprehensive analysis of recent advancements in Ti-Mg composites, emphasizing their advantages as implant materials in terms of tunable microstructural architectures and performance optimization potential. First, advanced fabrication techniques, including powder metallurgy (PM), melt infiltration, and liquid metal dealloying (LMD), compatible with Ti-Mg composites are categorized and analyzed. Second, the macrostructure design principle and microstructural characteristics of Ti-Mg composites are reviewed. Subsequently, the corresponding properties of Ti-Mg composites-specifically, mechanical properties, degradation behavior, and both in vitro and in vivo biological evaluations-are systematically discussed. Finally, the challenges and future prospects of Ti-Mg composites are addressed. STATEMENT OF SIGNIFICANCE: Ti-Mg composites with partial degradation characteristics have emerged as a frontier research domain for next-generation bioactive metallic implants. The rapid evolution of advanced manufacturing technologies, particularly high-pressure solid-state sintering, additive manufacturing and liquid metal dealloying, has enabled unprecedented opportunities for biomimetic structural engineering, microstructure optimization, and performance enhancement in these hybrid systems. This review provides a comprehensive analysis of the processing-structure-property relationship in Ti-Mg composites, while critically evaluating current limitations and outlining potential development strategies. The aim of this work is to offer essential insights into bioactive metallic implants with region-specific degradation profiles, thereby facilitating their clinical translation through material innovation. Copyright © 2025. Published by Elsevier Inc. DOI: 10.1016/j.actbio.2025.07.032 PMID: 40659149 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
研究方法综述 (Methods Overview)
采用系统性文献综述方法，检索和分析多个数据库中的相关研究文献。
数据总结 (Data Summary)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
主要发现 (Key Findings)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
结论 (Conclusions)
该综述为相关领域研究提供了全面的参考框架。
实践意义 (Practical Significance)
对推动学科交叉融合和研究创新具有重要价值。