Advances in the detection technology of drug and toxin protein adducts in forensic science
📄 英文摘要 English Abstract
Chinese Journal Of Analysis Laboratory 分析试验室 In forensic science, the timely and rapid detection of drugs and toxins in cases of poisoning is the focus of work. Some drugs and toxins, upon entering the body, undergo extensive and complex biological reactions with endogenous subs... 在法庭科学领域的中毒案(事)件中, 及时快速开展药毒物检验是工作的重点。部分药毒物进入机体后, 在短时间内与体内的内源性物质发生广泛且复杂的生物学反应, 导致药毒物原药定性检测结果出现假阴性现象。药毒物蛋白加合物作为中毒确证的生物标志物之一, 其在体内稳定性高、 持续时间长,对于确证中毒情况和进行溯源分析至关重要。本文简要概述了药毒物蛋白加合物的研究现状, 介绍了药毒物蛋白的加合机制和加合位点, 着重总结了药毒物蛋白加合物的分离提
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
In forensic science, the timely and rapid detection of drugs and toxins in cases of poisoning is the focus of work. Some drugs and toxins, upon entering the body, undergo extensive and complex biological reactions with endogenous substances, leading to false-negative results in qualitative detection of the original drugs. Drug-toxin protein adducts are biomarkers for confirming poisoning, with high stability and long duration in the body, and are important for confirming poisoning and source tracing.
Methods:
The article briefly summarizes the research status of drug-toxin protein adducts, introduces the adduction mechanisms and adduction sites of drug-toxin proteins, and focuses on the separation and purification of drug-toxin protein adducts.
Results:
The abstract reports that drug-toxin protein adducts can serve as biomarkers for confirming poisoning because of their high in-body stability and long duration. It also notes that qualitative detection of original drugs may produce false-negative results due to extensive and complex biological reactions after drugs and toxins enter the body.
Data Summary:
No quantitative results or key statistics are provided in the abstract.
Conclusions:
Drug-toxin protein adducts are important biomarkers for confirming poisoning and for source tracing, owing to their high stability and long duration in the body.
Practical Significance:
Drug-toxin protein adducts can support timely and rapid forensic detection of drugs and toxins in poisoning cases, help confirm poisoning, and enable source tracing, particularly when original drug qualitative detection may yield false-negative results.
📋 中文结构化总结 Chinese Structured Summary
背景:
在法医学中，中毒案件中药物和毒素的及时、快速检测是工作重点。某些药物和毒素进入人体后，会与内源性物质发生广泛而复杂的生物反应，导致对原形药物进行定性检测时出现假阴性结果。药物-毒素蛋白加合物是确认中毒的生物标志物，其在体内稳定性高、存在时间长，对确认中毒和溯源具有重要意义。
方法:
本文简要总结了药物-毒素蛋白加合物的研究现状，介绍了药物-毒素蛋白的加合机制和加合位点，并重点阐述了药物-毒素蛋白加合物的分离与纯化。
结果:
摘要指出，药物-毒素蛋白加合物由于在体内稳定性高、存在时间长，可作为确认中毒的生物标志物。同时指出，药物和毒素进入人体后，由于发生广泛而复杂的生物反应，原形药物的定性检测可能出现假阴性结果。
数据摘要:
摘要中未提供定量结果或关键统计数据。
结论:
药物-毒素蛋白加合物由于在体内稳定性高、存在时间长，是确认中毒和溯源的重要生物标志物。
实际意义:
药物-毒素蛋白加合物可支持中毒案件中药物和毒素的及时、快速法医检测，有助于确认中毒并进行溯源，尤其是在原形药物定性检测可能出现假阴性结果时。