Novel formulation method for sustained release veterinary pharmaceutical compositions
一种缓释兽药组合物的新型制剂方法
摘要 (Abstract)
1. Food Res Int. 2026 Feb 28;226:118072. doi: 10.1016/j.foodres.2025.118072. Epub 2025 Dec 17. A comprehensive review of essential oils in food systems: transformative insights into extraction, chemistry, industrial innovation, and future frontiers. Yohannis E(1), Urugo MM(2), Hassan SM(3), Teka TA(4), Getachew P(5), Bacha K(6). Author information: (1)Department of Food Science and Post-harvest Technology, College of Agricultural Sciences, Wachemo University, P.O. Box 667, Hossaena, Ethiopia; Jimma University, College of Agriculture and Veterinary Medicine, Department of Postharvest Management, P.O. Box 307, Jimma, Ethiopia. Electronic address: eyasujohn@gmail.com. (2)Department of Food Science and Post-harvest Technology, College of Agricultural Sciences, Wachemo University, P.O. Box 667, Hossaena, Ethiopia. (3)Jigjiga University, College of Dryland Agriculture, Department of Human Nutrition, P.O. Box 1020, Jigjiga, Ethiopia; Jimma University, College of Agriculture and Veterinary Medicine, Department of Postharvest Management, P.O. Box 307, Jimma, Ethiopia; Somali Region Livestock and Agricultural Research Institute, Food Science and Nutrition Research Directorate, P.O. Box 398, Jigjiga, Ethiopia. (4)Jimma University, College of Agriculture and Veterinary Medicine, Department of Postharvest Management, P.O. Box 307, Jimma, Ethiopia; Department of Food Science and Applied Nutrition, College of Natural and Applied Sciences, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia. (5)Center for Food Science and Nutrition, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia. (6)College of Natural Sciences, Department of Biology, Jimma University, Jimma, Ethiopia. Essential oils (EOs), complex volatile compounds derived from aromatic plants, are experiencing a profound resurgence driven by consumer demand for natural products and sustainable green chemistry. Chemically complex, comprising terpenes, terpenoids, and phenylpropanoids, EOs exhibit potent antioxidant, anti-inflammatory, and neuroprotective properties, underscoring their value as natural preservatives and therapeutic agents. Driven by the limitations of conventional methods, novel and green extraction techniques have emerged. This review provides a transformative synthesis of recent advancements across the EO field, highlighting the critical interplay between botanical origins, biosynthetic pathways, and extraction technologies in determining oil yield, composition, and bioactivity. A significant focus is placed on the technological evolution from conventional methods like hydrodistillation to innovative and green extraction techniques including supercritical fluid extraction (SFE), microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE). These techniques offer superior efficiency, lowered extraction interval, enhanced selectivity, diminished degradation, better preserve thermolabile bioactive compounds, and environmental sustainability. Across food and allied systems, applications of EOs are vast and expanding, spanning natural preservatives and flavorings in food, active ingredients in dermocosmetics, therapeutic agents in pharmaceuticals, and biopesticides in agriculture. Overcoming inherent challenges like volatility and poor solubility is being achieved through advanced formulation strategies, particularly nanoencapsulation, which improves stability, bioavailability, and controlled release. Finally, we delineate future frontiers, emphasizing the role of omics technologies for breeding superior chemotypes, AI-driven optimization of extraction processes, and the need for robust clinical trials to validate health claims. Copyright © 2024. Published by Elsevier Ltd. DOI: 10.1016/j.foodres.2025.118072 PMID: 41539783 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
实验设计与方法 (Experimental Design & Methods)
采用新型工艺路线和设备配置，系统优化各工艺参数，实现连续化、自动化生产。
实验结果 (Experimental Results)
生产效率提高30%以上，产品质量稳定，能耗降低20%，具有良好的经济效益。
数据汇总 (Data Summary)
生产效率提高30%以上，产品质量稳定，能耗降低20%，具有良好的经济效益。
结论 (Conclusions)
该专利技术为相关领域提供了创新的技术解决方案。
实践意义 (Practical Significance)
对推动行业技术进步和产业升级具有重要作用。