Research Progress on Exosome Application in Drug Delivery

⚡ 摘要

外泌体在药物递送中的应用研究进展

作者通过文献检索,对国内外近20年蛋白多肽类药物在纳米粒、脂质体、传递体、微球、水凝胶等新型给药系统的研究按照载体材料、所用技术、性能或给药途径等进行分类介绍,为蛋白多肽类药物新制剂的开发和应用提供参考。结果发现研究较多的蛋白多肽类纳米粒有聚乳酸-羟基乙酸共聚物纳米粒、壳聚糖纳米粒、固体脂质纳米粒和无机纳米粒;脂质体有长循环脂质体、靶向脂质体、长循环靶向脂质体和多囊脂质体;微球有口服微球、注射微球和鼻黏膜给药微球;水凝胶主要为环境敏感型水凝胶,如温度敏感型水凝胶和pH... 期刊 Advanced Applied Materials 发表日期 2019 ISSN 2003-0789 DOI 10.36822/adv.app.mater.201910 类型原创研究 (Original Research)

📄 英文摘要 English Abstract

cell-to-cell communication. The most studied extracellular vesicles are exosomes. Exosomes are discoid vesicles with diameters between 30 and 150 nm. They have good delivery abilities, and many studies have shown that as novel drug delivery systems exosome have low immunogenicity, high biocompatibility, and are a powerful and novel delivery platform for disease treatment. In this review, exosome drug-loading methods and the latest research results for their use in drug delivery are summarized to facilitate expansion of exosome applications in cancer treatment.

📄 中文摘要 Chinese Abstract

中文

细胞间通讯。研究最为广泛的外泌体是外泌体。外泌体是直径在30至150纳米之间的盘状囊泡。它们具有良好的递送能力，许多研究表明，作为新型药物递送系统，外泌体具有低免疫原性、高生物相容性，是一种强大而新颖的疾病治疗递送平台。

📋 英文结构化总结 English Structured Summary

摘要整理

Background:

Methods:

In this review, exosome drug-loading methods and the latest research results for their use in drug delivery are summarized.

Results:

many studies have shown that as novel drug delivery systems exosome have low immunogenicity, high biocompatibility, and are a powerful and novel delivery platform for disease treatment.

Data Summary:

Exosomes are discoid vesicles with diameters between 30 and 150 nm.

Conclusions:

to facilitate expansion of exosome applications in cancer treatment.

Practical Significance:

as novel drug delivery systems exosome have low immunogenicity, high biocompatibility, and are a powerful and novel delivery platform for disease treatment.

📋 中文结构化总结 Chinese Structured Summary

中文

背景:

方法:

本文综述了外泌体的载药方法及其在药物递送中的最新研究成果。

结果:

许多研究表明，作为新型药物递送系统，外泌体具有低免疫原性、高生物相容性，是一种强大而新颖的疾病治疗递送平台。

数据摘要:

外泌体是直径在30至150纳米之间的盘状囊泡。

结论:

以促进外泌体在癌症治疗中的应用拓展。

实际意义:

作为新型药物递送系统，外泌体具有低免疫原性、高生物相容性，是一种强大而新颖的疾病治疗递送平台。