[Research Progress in the Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drugs Targeting Spike Protein].

⚡ 摘要

靶向刺突蛋白的抗严重急性呼吸综合征冠状病毒2药物研究进展

作者 Jia-Yi Geng; Hao Sun; Qiang Ni; Qiuyu Li 期刊 PubMed 发表日期 2022 DOI 10.3881/j.issn.1000-503x.15002 类型 原创研究 (Original Research)

📄 英文摘要 English Abstract

EN

The coronavirus disease 2019(COVID-19) caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is spreading around the world,while the specific drugs targeting SARS-CoV-2 are still under development.On the basis of the biological characteristics of SARS-CoV-2 and the key protein(spike protein) for viral replication,this paper introduces the research progress in the action sites of related drugs,providing information for clinical application and ideas for development of anti-SARS-CoV-2 drugs.

📄 中文摘要 Chinese Abstract

中文
由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)正在全球范围内传播,而针对SARS-CoV-2的特效药物仍在研发之中。

📋 英文结构化总结 English Structured Summary

摘要整理

EN

Background:

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading around the world, while the specific drugs targeting SARS-CoV-2 are still under development.

Methods:

On the basis of the biological characteristics of SARS-CoV-2 and the key protein (spike protein) for viral replication, this paper introduces the research progress in the action sites of related drugs.

Results:

This paper introduces the research progress in the action sites of related drugs.

Data Summary:

No quantitative results or key statistics are provided in the text.

Conclusions:

Providing information for clinical application and ideas for development of anti-SARS-CoV-2 drugs.

Practical Significance:

Providing information for clinical application and ideas for development of anti-SARS-CoV-2 drugs.

📋 中文结构化总结 Chinese Structured Summary

中文

背景:

由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)正在全球范围内传播,而针对SARS-CoV-2的特效药物仍在研发之中。

方法:

本文基于SARS-CoV-2的生物学特性及病毒复制的关键蛋白(刺突蛋白),介绍了相关药物作用靶点的研究进展。

结果:

本文介绍了相关药物作用靶点的研究进展。

数据摘要:

文中未提供定量结果或关键统计数据。

结论:

为临床应用提供信息,并为抗SARS-CoV-2药物的研发提供思路。

实际意义:

为临床应用提供信息,并为抗SARS-CoV-2药物的研发提供思路。