Small RNAs big impact: a review on microRNA-mediated tolerance in wheat under terminal heat.
小RNA大影响：microRNA介导的小麦末端热耐受性综述
📄 英文摘要 English Abstract
MicroRNAs (miRNAs) are key regulators of gene expression in plant responses to abiotic stresses, including heat stress. High temperatures during the critical developmental stages of wheat (Triticum aestivum L.) drastically limit growth and production. Recent research has found that specific miRNAs regulate molecular complexes and physiological responses by targeting transcription factors, heat shock proteins, and signaling components, thereby modulating heat stress tolerance pathways. This review highlights current knowledge about heat-responsive miRNAs in wheat, including their validated targets and functional involvement in thermotolerance. In addition, we summarized the potential CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats /CRISPR associated protein 9) genome editing tool for precise alteration of miRNA genes or their targets, degradome profiling, the secondary structure of miRNA, and how interplay of miRNAs with HSFs and HSPs in target gene regulation to improve heat resilience. A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
MicroRNAs (miRNAs) are key regulators of gene expression in plant responses to abiotic stresses, including heat stress. High temperatures during the critical developmental stages of wheat (Triticum aestivum L.) drastically limit growth and production. Recent research has found that specific miRNAs regulate molecular complexes and physiological responses by targeting transcription factors, heat shock proteins, and signaling components, thereby modulating heat stress tolerance pathways.
Methods:
N/A - Review article
Results:
This review highlights current knowledge about heat-responsive miRNAs in wheat, including their validated targets and functional involvement in thermotolerance. In addition, we summarized the potential CRISPR/Cas9 genome editing tool for precise alteration of miRNA genes or their targets, degradome profiling, the secondary structure of miRNA, and how interplay of miRNAs with HSFs and HSPs in target gene regulation to improve heat resilience.
Data Summary:
(No quantitative results or key statistics are provided in the text.)
Conclusions:
A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming.
Practical Significance:
A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming.
📋 中文结构化总结 Chinese Structured Summary
背景:
MicroRNAs（miRNAs）是植物响应非生物胁迫（包括热胁迫）过程中基因表达的关键调控因子。小麦（Triticum aestivum L.）关键发育阶段的高温严重限制了其生长和产量。最新研究发现，特定miRNAs通过靶向转录因子、热激蛋白和信号组分来调控分子复合物和生理响应，从而调节热胁迫耐受通路。
方法:
不适用——综述类文章
结果:
本综述重点介绍了小麦中热响应miRNAs的最新研究进展，包括其已验证的靶标及参与耐热性的功能作用。此外，我们总结了CRISPR/Cas9基因组编辑工具在精确修饰miRNAs基因或其靶标方面的潜在应用、降解组分析、miRNAs的二级结构，以及miRNAs与HSFs和HSPs在靶基因调控中的互作机制，以提高小麦的热胁迫恢复力。
数据摘要:
（文中未提供定量结果或关键统计数据。）
结论:
全面理解miRNAs调控网络为开发气候适应性小麦品种提供了新思路，从而在全球变暖背景下保障粮食安全。
实践意义:
全面理解miRNAs调控网络为开发气候适应性小麦品种提供了新思路，从而在全球变暖背景下保障粮食安全。