Treating and preventing progression of cancer e.g. gastric cancer includes administering anti-programmed cell death protein 1 antibody and anti-human epidermal growth factor receptor 2 antibody-drug conjugate and cytotoxic molecule
治疗和预防癌症（如胃癌）进展包括施用抗程序性细胞死亡蛋白1抗体和抗人表皮生长因子受体2抗体-药物偶联物及细胞毒性分子
📄 英文摘要 English Abstract
生物来源蛋白纳米递药系统研究进展:以白蛋白、丝素蛋白和玉米醇溶蛋白为例 Polymer Bulletin 高分子通报 Drugs in traditional dosage forms have low bioavailability and it is difficult to achieve sustained release and targeted administration. Therefore, it is imperative to develop new dosage forms that meet the clinical needs of patients.... 传统给药剂型的药物生物利用度低,且难以实现缓释、定向给药,因此迫切需要开发新的剂型以满足临床需求。纳米递药系统具有可实现靶向给药的特点,引起了人们的广泛关注。其中蛋白质纳米递药系统可显著改善药物的水溶性和稳定性,降低药物的使用剂量以减轻副作用,生物相容性高并且在体内可降解,是一种具有潜在开发价值的生物有机材料。其中,白蛋白纳米粒、丝素蛋白纳米粒、玉米醇溶蛋白纳米粒3种不同生物来源的蛋白纳米粒是极具代表性
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
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Background Traditional dosage forms have low bioavailability and it is difficult to achieve sustained release and targeted administration. Therefore, it is imperative to develop new dosage forms that meet the clinical needs of patients. Nano drug delivery systems have attracted widespread attention due to their ability to achieve targeted drug delivery. Among them, protein nano delivery systems can significantly improve the water solubility and stability of drugs, reduce the dosage of drugs to alleviate side effects, have high biocompatibility, and are degradable in the body, making them a bio-organic material with potential development value.
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Methods This is a review article that examines the research progress of protein nano drug delivery systems, specifically using albumin nanoparticles, silk fibroin nanoparticles, and zein nanoparticles as representative examples from different biological sources.
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Results Protein nano delivery systems can significantly improve the water solubility and stability of drugs, reduce the dosage of drugs to alleviate side effects, have high biocompatibility, and are degradable in the body.
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Data Summary No quantitative results or key statistics are provided in the abstract.
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Conclusions Protein nano delivery systems are a bio-organic material with potential development value for improving drug delivery.
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Practical Significance These systems enable targeted drug delivery and sustained release, meeting clinical needs for improved bioavailability and reduced side effects.
📋 中文结构化总结 Chinese Structured Summary
背景:
传统剂型生物利用度低，难以实现缓释和靶向给药。因此，开发满足临床患者需求的新型剂型势在必行。纳米药物递送系统因其能够实现靶向药物递送而受到广泛关注。其中，蛋白质纳米递送系统可显著提高药物的水溶性和稳定性，降低药物剂量以减轻副作用，具有较高的生物相容性，且可在体内降解，是一种具有潜在开发价值的生物有机材料。
方法:
本文为综述文章，以白蛋白纳米颗粒、丝素蛋白纳米颗粒和玉米醇溶蛋白纳米颗粒为例，从不同生物来源阐述了蛋白质纳米药物递送系统的研究进展。
结果:
蛋白质纳米递送系统可显著提高药物的水溶性和稳定性，降低药物剂量以减轻副作用，具有较高的生物相容性，且可在体内降解。
数据摘要:
摘要中未提供定量结果或关键统计数据。
结论:
蛋白质纳米递送系统是一种具有潜在开发价值的生物有机材料，可用于改善药物递送。
实际意义:
这些系统能够实现靶向药物递送和缓释，满足提高生物利用度和减轻副作用的临床需求。