Research Progress of Pseudo-Proteins as Drug Carriers
伪蛋白质作为药物载体的研究进展
📄 英文摘要 English Abstract
Since the lungs are directly connected to the external environment and have a rich blood supply, they are susceptible to damage and tumor growth. However, the pharmacokinetics of traditional drugs in the lungs are limited when administered orally or intravenously, posing challenges for clinical treatment. Compared to traditional drug delivery methods, nano-based drug delivery systems (NDDSs) have the advantages of high drug loading capacity, strong targeting, low cellular toxicity, and extended circulation time in the blood. Stimuli-responsive materials, often referred to as “smart” materials, are a class of functional materials that can change their properties in response to various stimuli in both internal and external environments. Therefore, stimuli-responsive materials have gradually become promising candidates for NDDSs. To date, many stimuli-responsive NDDSs have been developed for treating lung diseases. Our review primarily summarizes the novel NDDSs that have emerged in recent years for treating common benign and malignant lesions in the lungs, based on stimuli-responsive materials. Finally, we discussed the existing issues in stimuli-responsive NDDSs and looked forward to their future development prospects.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
Since the lungs are directly connected to the external environment and have a rich blood supply, they are susceptible to damage and tumor growth. However, the pharmacokinetics of traditional drugs in the lungs are limited when administered orally or intravenously, posing challenges for clinical treatment. Compared to traditional drug delivery methods, nano-based drug delivery systems (NDDSs) have the advantages of high drug loading capacity, strong targeting, low cellular toxicity, and extended circulation time in the blood. Stimuli-responsive materials, often referred to as “smart” materials, are a class of functional materials that can change their properties in response to various stimuli in both internal and external environments. Therefore, stimuli-responsive materials have gradually become promising candidates for NDDSs.
Methods:
N/A - Review article
Results:
To date, many stimuli-responsive NDDSs have been developed for treating lung diseases. Our review primarily summarizes the novel NDDSs that have emerged in recent years for treating common benign and malignant lesions in the lungs, based on stimuli-responsive materials. Finally, we discussed the existing issues in stimuli-responsive NDDSs and looked forward to their future development prospects.
Data Summary:
No quantitative data or key statistics are presented in the provided text.
Conclusions:
We discussed the existing issues in stimuli-responsive NDDSs and looked forward to their future development prospects.
Practical Significance:
These stimuli-responsive NDDSs are applied for treating common benign and malignant lesions in the lungs.
📋 中文结构化总结 Chinese Structured Summary
背景:
由于肺部直接与外界环境相通且血供丰富，因此易受损伤并发生肿瘤生长。然而，传统药物经口服或静脉给药后在肺部的药代动力学受限，给临床治疗带来挑战。与传统药物递送方法相比，纳米药物递送系统（NDDSs）具有载药量高、靶向性强、细胞毒性低以及血液循环时间长等优点。刺激响应性材料通常被称为"智能"材料，是一类能够响应内外环境各种刺激而改变自身性能的功能性材料。因此，刺激响应性材料逐渐成为NDDSs领域极具前景的候选材料。
方法:
不适用——综述类文章
结果:
迄今为止，已有多种刺激响应性NDDSs被开发用于治疗肺部疾病。本综述主要总结了近年来基于刺激响应性材料开发的、用于治疗肺部常见良恶性病变的新型NDDSs。最后，我们讨论了刺激响应性NDDSs目前存在的问题，并展望了其未来发展前景。
数据摘要:
所提供文本中未呈现定量数据或关键统计数据。
结论:
我们讨论了刺激响应性NDDSs目前存在的问题，并展望了其未来发展前景。
实际意义:
这些刺激响应性NDDSs被应用于治疗肺部常见良恶性病变。