Profiling the Misfolded Proteome in Human Disease
人类疾病中错误折叠蛋白质组的分析
摘要 (Abstract)
<jats:title>Abstract</jats:title><jats:p>Changes in protein homeostasis are broadly implicated in many disease states, including amyloidoses, neurodegenerative diseases, cancer, and normal aging. Although this relationship has been fruitful for identifying and developing therapeutic strategies, it is challenging to identify which proteins are misfolding. New technologies have recently emerged that enable proteome‐wide interrogation of protein conformation and stability. In this review, we describe these technologies, and how they have been used to identify proteins whose folding changes between disease states. We discuss some of the challenges in this emerging field, and the potential for misfolded protein profiling to provide insight into human disease.</jats:p>
实验设计与方法 (Experimental Design & Methods)
采用系统性文献综述方法，检索和分析多个数据库中的相关研究文献。
实验结果 (Experimental Results)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
数据汇总 (Data Summary)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
结论 (Conclusions)
该综述为相关领域研究提供了全面的参考框架。
实践意义 (Practical Significance)
对推动学科交叉融合和研究创新具有重要价值。