Advances in spray drying technology for anti-tubercular formulation development: A comprehensive review

Abstract Global health is still seriously threatened by tuberculosis (TB), especially considering the increasing incidence of strains of the disease that are extensively drug-resistant (XDR) and multidrug-resistant (MDR). These TB superbugs necessitate innovative therapeutic strategies to improve treatment efficacy and patient compliance. Spray-drying technology has emerged as a promising method for the formulation of anti-TB therapies, offering advantages, such as enhanced drug stability, targeted delivery, and controlled release profiles. Key aspects include the principles of spray drying, the physicochemical characteristics of the resulting powders, and their impact on drug delivery to the lungs. Research focuses on optimizing these formulations to improve drug delivery directly to the lungs, enhance bioavailability, and abate side effects. This review underscores the transformative potential of these innovative spray-drying techniques, offering an effective and patient-friendly treatment regimen for TB. Additionally, the review highlights the potential of spray-dried formulations in developing host-directed therapies, antimicrobial peptides, vaccines, phages, and monoclonal antibodies. By integrating multidisciplinary approaches and cutting-edge technologies, spray-dried formulations promise to revolutionize TB treatment, ultimately contributing to better patient outcomes and the global effort to eradicate this persistent disease. GRAPHICAL ABSTRACT

Background:

Global health is still seriously threatened by tuberculosis (TB), especially considering the increasing incidence of strains of the disease that are extensively drug-resistant (XDR) and multidrug-resistant (MDR). These TB superbugs necessitate innovative therapeutic strategies to improve treatment efficacy and patient compliance.

Methods:

N/A - Review article

Results:

Spray-drying technology has emerged as a promising method for the formulation of anti-TB therapies, offering advantages, such as enhanced drug stability, targeted delivery, and controlled release profiles. Key aspects include the principles of spray drying, the physicochemical characteristics of the resulting powders, and their impact on drug delivery to the lungs. Research focuses on optimizing these formulations to improve drug delivery directly to the lungs, enhance bioavailability, and abate side effects. This review underscores the transformative potential of these innovative spray-drying techniques, offering an effective and patient-friendly treatment regimen for TB. Additionally, the review highlights the potential of spray-dried formulations in developing host-directed therapies, antimicrobial peptides, vaccines, phages, and monoclonal antibodies.

Data Summary:

No quantitative results or key statistics are provided in the abstract.

Conclusions:

By integrating multidisciplinary approaches and cutting-edge technologies, spray-dried formulations promise to revolutionize TB treatment, ultimately contributing to better patient outcomes and the global effort to eradicate this persistent disease.

Practical Significance:

These spray-dried formulations offer a patient-friendly treatment regimen for TB and have potential in developing host-directed therapies, antimicrobial peptides, vaccines, phages, and monoclonal antibodies, contributing to better patient outcomes and the global effort to eradicate TB.