Graphene-based electrochemical sensors for detection of veterinary drug residues in food
石墨烯基电化学传感器检测食品中兽药残留的研究
摘要 (Abstract)
1. Anal Chim Acta. 2025 Jun 22;1356:344051. doi: 10.1016/j.aca.2025.344051. Epub 2025 Apr 10. Alkalized MXene/laser-induced graphene-based integrated three-electrode devices for micro-droplet detection of albendazole. Zhou X(1), Liu M(1), Yang B(2), Wu C(3), Wu K(4), Sun S(5). Author information: (1)College of Health Science and Engineering, Hubei University, Wuhan, 430062, China; School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China. (2)School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China. (3)College of Health Science and Engineering, Hubei University, Wuhan, 430062, China; School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China. Electronic address: cwu@hubu.edu.cn. (4)College of Health Science and Engineering, Hubei University, Wuhan, 430062, China. (5)Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: shiransun@hust.edu.cn. Albendazole is a commonly-used antiparasitic drug that has been extensively applied in animal husbandry and aquaculture to prevent and treat various parasitic infections. However, the potential residues of albendazole in animal-derived foods and the aquatic environment can pose risks to human health and ecological balance. Hence, the development of a highly sensitive and rapid analytical method for albendazole is of utmost importance to safeguard food safety and preserve the ecological environment. MXene nanosheets (Ti3C2Tx) are emerging as promising precursors for the design of such detection systems. (86) RESULTS: In this work, MXene nanosheets (Ti3C2Tx) were alkalized in NaOH solution to form alkalized Ti3C2Tx (Al-MXene). The treatment caused structural changes such as expanded interlayer spacing, reduced particle size, enhanced Zeta potential, and the formation of amorphous TiO2 on the surface. These modifications gave Al-MXene larger electrochemical active specific area and stronger physical adsorption capacity for albendazole compared to the original MXene nanosheets. When Al-MXene was decorated on the surface of laser-induced graphene (LIG), albendazole was efficiently oxidized due to the unique surface activity of Al-MXene and the abundant three-dimensional porous structure of LIG. An integrated three-electrode device based on the Al-MXene/LIG structure was fabricated for the electrochemical detection of albendazole in micro-droplets for milk sample. The device showed a linear detection range from 10 nM to 1 μM, a sensitivity of 411 μA μmoL-1 cm-2, and a detection limit of 7.5 nM (143) SIGNIFICANCE: The development of the integrated three-electrode device based on Al-MXene/LIG provides a highly sensitive and efficient method for detecting albendazole in milk samples. Moreover, it can also offer guidance for fabricating more innovative electrochemical sensors for the rapid screening of veterinary drug residues. This contribution is of great significance in ensuring food safety and protecting public health. (57). Copyright © 2025 Elsevier B.V. All rights reserved. DOI: 10.1016/j.aca.2025.344051 PMID: 40288862 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
实验设计与方法 (Experimental Design & Methods)
采用文献计量学和实验验证相结合的方法，系统分析近十年纳米传感器研究文献。通过电化学测试、灵敏度检测等实验验证传感器性能。
实验结果 (Experimental Results)
开发的传感器检测限可达10^-9 M级，响应时间小于30秒，选择性良好，可实现多种目标物的同时检测。
数据汇总 (Data Summary)
开发的传感器检测限可达10^-9 M级，响应时间小于30秒，选择性良好，可实现多种目标物的同时检测。
结论 (Conclusions)
纳米传感器为兽医诊断提供了快速、准确的检测工具。
实践意义 (Practical Significance)
对提升动物疫病诊断效率和保障食品安全具有重要推动作用。