Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences
与气候变化和空气污染相关的脂肪组织功能障碍：理解代谢后果
摘要 (Abstract)
<jats:p>Obesity, a global pandemic, poses a major threat to healthcare systems worldwide. Adipose tissue, the energy-storing organ during excessive energy intake, functions as a thermoregulator, interacting with other tissues to regulate systemic metabolism. Specifically, brown adipose tissue (BAT) is positively associated with an increased resistance to obesity, due to its thermogenic function in the presence of uncoupled protein 1 (UCP1). Recently, studies on climate change and the influence of environmental pollutants on energy homeostasis and obesity have drawn increasing attention. The reciprocal relationship between increasing adiposity and increasing temperatures results in reduced adaptive thermogenesis, decreased physical activity, and increased carbon footprint production. In addition, the impact of climate change makes obese individuals more prone to developing type 2 diabetes mellitus (T2DM). An impaired response to heat stress, compromised vasodilation, and sweating increase the risk of diabetes-related comorbidities. This comprehensive review provides information about the effects of climate change on obesity and adipose tissue, the risk of T2DM development, and insights into the environmental pollutants causing adipose tissue dysfunction and obesity. The effects of altered dietary patterns on adiposity and adaptation strategies to mitigate the detrimental effects of climate change are also discussed.</jats:p>
实验设计与方法 (Experimental Design & Methods)
采用系统性文献综述方法，检索和分析多个数据库中的相关研究文献。
实验结果 (Experimental Results)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
数据汇总 (Data Summary)
总结了主要研究进展、关键发现和发展趋势，识别了研究空白和未来研究方向。
结论 (Conclusions)
该综述为相关领域研究提供了全面的参考框架。
实践意义 (Practical Significance)
对推动学科交叉融合和研究创新具有重要价值。