Biological and thermodynamic stabilization of lipid-based delivery systems through natural biopolymers; controlled release and molecular dynamics simulations
通过天然生物聚合物实现脂质递送系统的生物和热力学稳定化：控释与分子动力学模拟
📄 英文摘要 English Abstract
Nowadays, the use of lipid-based nanocarriers for the targeted and controlled delivery of a variety of hydrophobic and hydrophilic bioactive-compounds and drugs has increased significantly. However, challenges such as thermodynamic instability, oxidation, and degradation of lipid membranes, as well as the unintended release of loaded compounds, have limited the use of these systems in the food and pharmaceutical industries. Therefore, the present study reviews the latest achievements in evaluating the characteristics, production methods, challenges, functional, and biological stabilization strategies of lipid-based carriers (including changes in formulation composition, structural modification, membrane-rigidity, and finally monolayer or multilayer coating with biopolymers) in different conditions, as well as molecular dynamics simulations. The scientists' findings indicate the effect of natural biopolymers (such as chitosan, calcium alginate, pectin, dextran, xanthan, caseins, gelatin, whey-proteins, zein, and etc.) in modifying the external structure of lipid-based carriers, improving thermodynamic stability and resistance of membranes to physicochemical and mechanical tensions. However, depending on the type of bioactive compound as well as the design and production goals of the delivery-system, selecting the appropriate biopolymer has a significant impact on the stability of vesicles and maintaining the bioaccessibility of the loaded-compounds due to the stresses caused by the storage-conditions, formulation, processing and gastrointestinal tract.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
Nowadays, the use of lipid-based nanocarriers for the targeted and controlled delivery of a variety of hydrophobic and hydrophilic bioactive-compounds and drugs has increased significantly. However, challenges such as thermodynamic instability, oxidation, and degradation of lipid membranes, as well as the unintended release of loaded compounds, have limited the use of these systems in the food and pharmaceutical industries. Therefore, the present study reviews the latest achievements in evaluating the characteristics, production methods, challenges, functional, and biological stabilization strategies of lipid-based carriers (including changes in formulation composition, structural modification, membrane-rigidity, and finally monolayer or multilayer coating with biopolymers) in different conditions, as well as molecular dynamics simulations.
Methods:
The present study reviews the latest achievements in evaluating the characteristics, production methods, challenges, functional, and biological stabilization strategies of lipid-based carriers (including changes in formulation composition, structural modification, membrane-rigidity, and finally monolayer or multilayer coating with biopolymers) in different conditions, as well as molecular dynamics simulations.
Results:
The scientists' findings indicate the effect of natural biopolymers (such as chitosan, calcium alginate, pectin, dextran, xanthan, caseins, gelatin, whey-proteins, zein, and etc.) in modifying the external structure of lipid-based carriers, improving thermodynamic stability and resistance of membranes to physicochemical and mechanical tensions. However, depending on the type of bioactive compound as well as the design and production goals of the delivery-system, selecting the appropriate biopolymer has a significant impact on the stability of vesicles and maintaining the bioaccessibility of the loaded-compounds due to the stresses caused by the storage-conditions, formulation, processing and gastrointestinal tract.
Data Summary:
No quantitative results or key statistics are presented in the provided abstract; only qualitative findings regarding the effect of natural biopolymers on lipid-based carriers are described.
Conclusions:
Depending on the type of bioactive compound as well as the design and production goals of the delivery-system, selecting the appropriate biopolymer has a significant impact on the stability of vesicles and maintaining the bioaccessibility of the loaded-compounds due to the stresses caused by the storage-conditions, formulation, processing and gastrointestinal tract.
Practical Significance:
The use of lipid-based nanocarriers for targeted and controlled delivery of bioactive-compounds and drugs is relevant to the food and pharmaceutical industries, and the stabilization strategies reviewed (including biopolymer coatings) aim to overcome limitations such as thermodynamic instability, oxidation, degradation, and unintended release, thereby improving practical applicability.
📋 中文结构化总结 Chinese Structured Summary
背景:
如今，利用脂质基纳米载体对多种疏水性和亲水性生物活性化合物和药物进行靶向和控释递送的应用已显著增加。然而，诸如热力学不稳定性、脂质膜的氧化和降解以及负载化合物意外释放等挑战限制了这些系统在食品和制药行业中的应用。因此，本文综述了在评估脂质基载体特性、制备方法、挑战、功能性和生物稳定化策略方面的最新进展（包括在不同条件下改变配方组成、结构修饰、膜刚性以及最终的单层或多层生物聚合物涂层），以及分子动力学模拟方面的研究。
方法:
本文综述了在评估脂质基载体特性、制备方法、挑战、功能性和生物稳定化策略方面的最新进展（包括在不同条件下改变配方组成、结构修饰、膜刚性以及最终的单层或多层生物聚合物涂层），以及分子动力学模拟方面的研究。
结果:
研究人员的发现表明，天然生物聚合物（如壳聚糖、海藻酸钙、果胶、葡聚糖、黄原胶、酪蛋白、明胶、乳清蛋白、玉米醇溶蛋白等）在修饰脂质基载体的外部结构、改善热力学稳定性以及增强膜对物理化学和机械应力的抵抗性方面具有显著作用。然而，根据生物活性化合物的类型以及递送系统的设计和生产目标，选择合适的生物聚合物对囊泡的稳定性以及维持负载化合物的生物可及性具有显著影响，这归因于储存条件、配方、加工过程和胃肠道所引起的应力。
数据摘要:
所提供的摘要中未呈现定量结果或关键统计数据；仅描述了天然生物聚合物对脂质基载体影响的定性发现。
结论:
根据生物活性化合物的类型以及递送系统的设计和生产目标，选择合适的生物聚合物对囊泡的稳定性以及维持负载化合物的生物可及性具有显著影响，这归因于储存条件、配方、加工过程和胃肠道所引起的应力。
实际意义:
利用脂质基纳米载体对生物活性化合物和药物进行靶向和控释递送与食品和制药行业密切相关，本文所综述的稳定化策略（包括生物聚合物涂层）旨在克服热力学不稳定性、氧化、降解和意外释放等局限性，从而提高实际应用价值。