Association between toxicity-index of diquat and in-hospital mortality in patients with acute diquat poisoning: a retrospective cohort study
急性百草枯中毒患者中百草枯毒性指数与院内死亡率的相关性：一项回顾性队列研究
📄 英文摘要 English Abstract
BACKGROUND: This study investigates the impact of diquat toxicity levels on in-hospital mortality rates among patients with acute diquat poisoning. It aims to clarify the relationship between diquat toxicity scores and the likelihood of death during hospitalization. METHODS: A retrospective cohort study was conducted on 98 individuals with acute diquat poisoning. Data on post-ingestion time, initial diquat plasma concentration, and clinical outcomes were systematically collected for all participants. The toxicity-index of diquat was calculated based on post-ingestion time and initial diquat plasma concentration. Logistic regression analysis was utilized to assess the association between the toxicity-index of diquat and in-hospital mortality rates, adjusting for potential confounding variables such as age, comorbidities, and treatment interventions. RESULTS: values for interaction were >0.05). CONCLUSIONS: The study found that higher diquat toxicity-index values correlate with increased in-hospital mortality in acute diquat poisoning cases, indicating that the toxicity-index could be a useful biomarker for assessing mortality risk.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
This study investigates the impact of diquat toxicity levels on in-hospital mortality rates among patients with acute diquat poisoning. It aims to clarify the relationship between diquat toxicity scores and the likelihood of death during hospitalization.
Methods:
A retrospective cohort study was conducted on 98 individuals with acute diquat poisoning. Data on post-ingestion time, initial diquat plasma concentration, and clinical outcomes were systematically collected for all participants. The toxicity-index of diquat was calculated based on post-ingestion time and initial diquat plasma concentration. Logistic regression analysis was utilized to assess the association between the toxicity-index of diquat and in-hospital mortality rates, adjusting for potential confounding variables such as age, comorbidities, and treatment interventions.
Results:
values for interaction were >0.05).
Data Summary:
values for interaction were >0.05).
Conclusions:
The study found that higher diquat toxicity-index values correlate with increased in-hospital mortality in acute diquat poisoning cases.
Practical Significance:
indicating that the toxicity-index could be a useful biomarker for assessing mortality risk.
📋 中文结构化总结 Chinese Structured Summary
背景:
本研究探讨敌草快毒性水平对急性敌草快中毒患者住院死亡率的影响，旨在明确敌草快毒性评分与住院期间死亡风险之间的关系。
方法:
对98例急性敌草快中毒患者进行回顾性队列研究，系统收集所有受试者的服毒后时间、初始敌草快血浆浓度及临床结局等数据。根据服毒后时间和初始敌草快血浆浓度计算敌草快毒性指数。采用Logistic回归分析评估敌草快毒性指数与住院死亡率之间的关联，并对年龄、合并症及治疗干预等潜在混杂因素进行校正。
结果:
交互作用P值均>0.05。
数据总结:
交互作用P值均>0.05。
结论:
研究发现，敌草快毒性指数值越高，急性敌草快中毒患者的住院死亡率越高。
实际意义:
提示敌草快毒性指数可作为评估死亡风险的有用生物标志物。