Advancing Drug Delivery with Plant Protein-based Nanoparticles: A Comprehensive Overview
利用植物蛋白纳米颗粒推进药物递送：全面概述
摘要 (Abstract)
<jats:sec> <jats:title/> <jats:p>The advancement of nanotechnology has made it possible to deliver small molecular drugs in nano-sized particles to target tissues. In this context, natural biomolecules, such as proteins, have gained significant attention as a safer alternative to synthetic polymers commonly used in nanoparticle production. Plant proteins, in particular, are preferred over animal proteins due to their lower risk of causing allergic reactions. Notable plant proteins include zein, soy protein, and wheat protein (gliadin, gluten). Plant protein nanoparticles can be fabricated using various methods, including emulsion, electrospray, desolvation, and complex coacervation, utilizing plant proteins like zein, gliadin, legumin, and soy protein. This review provides an overview of several plant proteins, their applications as excipients or vehicles in drug delivery, and the methods employed to fabricate plant protein nanoparticles. The review aims to shed light on the utilization of natural proteins as alternative excipients in nanotechnology.</jats:p> </jats:sec>
研究方法综述 (Methods Overview)
采用结构生物学、计算机模拟和实验验证相结合的方法，系统分析蛋白质结构和功能关系。通过分子对接、动力学模拟等技术预测药物-靶点相互作用。
数据总结 (Data Summary)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
主要发现 (Key Findings)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
结论 (Conclusions)
基于蛋白质的药物研发策略为创新药物开发提供了新方向。
实践意义 (Practical Significance)
对推动靶向药物研发和精准医疗发展具有重要科学价值。