Ti2C3 MXene-based nanocomposite as an intelligent nanoplatform for efficient mild hyperthermia treatment
基于Ti₂C₃ MXene的纳米复合材料作为高效温和热疗治疗的智能纳米平台
📄 英文摘要 English Abstract
Photothermal therapy (PTT) has attracted much attention due to its less invasive, controllable and highly effective nature. However, PTT also suffers from intrinsic cancer resistance mediated by cell survival pathways. These survival pathways are regulated by a variety of proteins, among which heat shock protein (HSP) triggers thermotolerance and protects tumor cells from hyperthermia-induced apoptosis. Confronted by this challenge, we propose and validate here a novel MXene-based HSP-inhibited mild photothermal platform, which significantly enhances the sensitivity of tumor cells to heat-induced stress and thus improves the PPT efficacy. The Ti
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
Photothermal therapy (PTT) has attracted much attention due to its less invasive, controllable and highly effective nature. However, PTT also suffers from intrinsic cancer resistance mediated by cell survival pathways. These survival pathways are regulated by a variety of proteins, among which heat shock protein (HSP) triggers thermotolerance and protects tumor cells from hyperthermia-induced apoptosis.
Methods:
Confronted by this challenge, we propose and validate here a novel MXene-based HSP-inhibited mild photothermal platform.
Results:
The platform significantly enhances the sensitivity of tumor cells to heat-induced stress and thus improves the PPT efficacy.
Data Summary:
No quantitative data is provided in the extract.
Conclusions:
The platform improves the PPT efficacy.
Practical Significance:
Photothermal therapy (PTT) has attracted much attention due to its less invasive, controllable and highly effective nature.
📋 中文结构化总结 Chinese Structured Summary
背景:
光热疗法（PTT）因其微创性、可控性和高效性而备受关注。然而，PTT也面临由细胞存活通路介导的肿瘤固有抵抗。这些存活通路受多种蛋白质调控，其中热休克蛋白（HSP）会触发热耐受性，保护肿瘤细胞免受热疗诱导的凋亡。
方法:
面对这一挑战，我们在此提出并验证了一种新型的基于MXene的HSP抑制温和光热平台。
结果:
该平台显著增强了肿瘤细胞对应激性热诱导的敏感性，从而提高了PPT疗效。
数据摘要:
本摘要中未提供定量数据。
结论:
该平台提高了PPT疗效。
实际意义:
光热疗法（PTT）因其微创性、可控性和高效性而备受关注。