Drug eluting protein and polysaccharides-based biofunctionalized fabric textiles- pioneering a new frontier in tissue engineering: An extensive review
药物洗脱蛋白和多糖基生物功能化织物纺织品——组织工程的新前沿：一篇广泛的综述
摘要 (Abstract)
1. Int J Biol Macromol. 2024 May;268(Pt 1):131605. doi: 10.1016/j.ijbiomac.2024.131605. Epub 2024 Apr 17. Drug eluting protein and polysaccharides-based biofunctionalized fabric textiles- pioneering a new frontier in tissue engineering: An extensive review. Garg A(1), Alfatease A(2), Hani U(3), Haider N(4), Akbar MJ(5), Talath S(6), Angolkar M(1), Paramshetti S(1), Osmani RAM(7), Gundawar R(8). Author information: (1)Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSSAHER), Mysuru 570015, Karnataka, India. (2)Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia. Electronic address: afatease@kku.edu.sa. (3)Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia. Electronic address: uahmed@kku.edu.sa. (4)Department of Pathology, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. (5)Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia. Electronic address: mjakbar@iau.edu.sa. (6)Department of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates. Electronic address: sirajunisa@rakmhsu.ac.ae. (7)Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSSAHER), Mysuru 570015, Karnataka, India. Electronic address: riyazosmani@jssuni.edu.in. (8)Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India. Electronic address: gundawar.ravi@manipal.edu. In the ever-evolving landscape of tissue engineering, medicated biotextiles have emerged as a game-changer. These remarkable textiles have garnered significant attention for their ability to craft tissue scaffolds that closely mimic the properties of natural tissues. This comprehensive review delves into the realm of medicated protein and polysaccharide-based biotextiles, exploring a diverse array of fabric materials. We unravel the intricate web of fabrication methods, ranging from weft/warp knitting to plain/stain weaving and braiding, each lending its unique touch to the world of biotextiles creation. Fibre production techniques, such as melt spinning, wet/gel spinning, and multicomponent spinning, are demystified to shed light on the magic behind these ground-breaking textiles. The biotextiles thus crafted exhibit exceptional physical and chemical properties that hold immense promise in the field of tissue engineering (TE). Our review underscores the myriad applications of drug-eluting protein and polysaccharide-based textiles, including TE, tissue repair, regeneration, and wound healing. Additionally, we delve into commercially available products that harness the potential of medicated biotextiles, paving the way for a brighter future in healthcare and regenerative medicine. Step into the world of innovation with medicated biotextiles-where science meets the art of healing. Copyright © 2024 Elsevier B.V. All rights reserved. DOI: 10.1016/j.ijbiomac.2024.131605 PMID: 38641284 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
研究方法综述 (Methods Overview)
采用结构生物学、计算机模拟和实验验证相结合的方法，系统分析蛋白质结构和功能关系。通过分子对接、动力学模拟等技术预测药物-靶点相互作用。
数据总结 (Data Summary)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
主要发现 (Key Findings)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
结论 (Conclusions)
基于蛋白质的药物研发策略为创新药物开发提供了新方向。
实践意义 (Practical Significance)
对推动靶向药物研发和精准医疗发展具有重要科学价值。