Advancing Drug Delivery with Plant Protein-based Nanoparticles: A Comprehensive Overview
基于植物蛋白纳米颗粒推进药物递送：全面概述
📄 英文摘要 English Abstract
The advancement of nanotechnology has made it possible to deliver small molecular drugs in nano-sized particles to target tissues. In this context, natural biomolecules, such as proteins, have gained significant attention as a safer alternative to synthetic polymers commonly used in nanoparticle production. Plant proteins, in particular, are preferred over animal proteins due to their lower risk of causing allergic reactions. Notable plant proteins include zein, soy protein, and wheat protein (gliadin, gluten). Plant protein nanoparticles can be fabricated using various methods, including emulsion, electrospray, desolvation, and complex coacervation, utilizing plant proteins like zein, gliadin, legumin, and soy protein. This review provides an overview of several plant proteins, their applications as excipients or vehicles in drug delivery, and the methods employed to fabricate plant protein nanoparticles. The review aims to shed light on the utilization of natural proteins as alternative excipients in nanotechnology.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
Background:
The advancement of nanotechnology has made it possible to deliver small molecular drugs in nano-sized particles to target tissues. In this context, natural biomolecules, such as proteins, have gained significant attention as a safer alternative to synthetic polymers commonly used in nanoparticle production. Plant proteins, in particular, are preferred over animal proteins due to their lower risk of causing allergic reactions. Notable plant proteins include zein, soy protein, and wheat protein (gliadin, gluten).
Methods:
N/A - Review article
Results:
Plant protein nanoparticles can be fabricated using various methods, including emulsion, electrospray, desolvation, and complex coacervation, utilizing plant proteins like zein, gliadin, legumin, and soy protein. This review provides an overview of several plant proteins, their applications as excipients or vehicles in drug delivery, and the methods employed to fabricate plant protein nanoparticles.
Data Summary:
No quantitative results or key statistics are provided in the source text.
Conclusions:
The review aims to shed light on the utilization of natural proteins as alternative excipients in nanotechnology.
Practical Significance:
The review discusses the use of plant protein nanoparticles as excipients or vehicles in drug delivery, highlighting their real-world applications in nanotechnology.
📋 中文结构化总结 Chinese Structured Summary
背景:
纳米技术的进步使得将小分子药物以纳米级颗粒形式递送至靶组织成为可能。在此背景下，天然生物分子（如蛋白质）作为合成聚合物在纳米颗粒生产中更安全的替代品而受到广泛关注。植物蛋白因其引起过敏反应的风险低于动物蛋白而更受青睐。常见的植物蛋白包括玉米醇溶蛋白、大豆蛋白和小麦蛋白（麦胶蛋白、谷蛋白）。
方法:
不适用 - 综述文章
结果:
植物蛋白纳米颗粒可采用多种方法制备，包括乳化法、静电喷雾法、去溶剂法和复合凝聚法，使用的植物蛋白包括玉米醇溶蛋白、麦胶蛋白、豆球蛋白和大豆蛋白。本综述概述了几种植物蛋白、其作为药物递赋形剂或载体的应用，以及制备植物蛋白纳米颗粒所采用的方法。
数据总结:
源文本中未提供定量结果或关键统计数据。
结论:
本综述旨在阐明天然蛋白质作为纳米技术中替代赋形剂的应用。
实际意义:
本综述讨论了植物蛋白纳米颗粒作为药物递赋形剂或载体的应用，重点介绍了其在纳米技术中的实际应用。