Recent advances in functionalized ferrite nanoparticles: From fundamentals to magnetic hyperthermia cancer therapy
功能化铁氧体纳米粒子的最新进展：从基础到磁性热疗癌症治疗
摘要 (Abstract)
1. Colloids Surf B Biointerfaces. 2024 Feb;234:113754. doi: 10.1016/j.colsurfb.2024.113754. Epub 2024 Jan 14. Recent advances in functionalized ferrite nanoparticles: From fundamentals to magnetic hyperthermia cancer therapy. Zhang L(1), Li Q(1), Liu J(2), Deng Z(3), Zhang X(4), Alifu N(5), Zhang X(1), Yu Z(1), Liu Y(1), Lan Z(1), Wen T(6), Sun K(7). Author information: (1)School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China. (2)School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China. (3)School of Aerospace Engineering, Beijing Institute of Technology, Beijing 100081, PR China. (4)School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China; School of Aerospace Engineering, Beijing Institute of Technology, Beijing 100081, PR China; State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, PR China. (5)State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia/School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, PR China. (6)School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610072, PR China. Electronic address: halong@uestc.edu.cn. (7)School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, PR China. Electronic address: ksun@uestc.edu.cn. Cancers are fatal diseases that lead to most death of human beings, which urgently require effective treatments methods. Hyperthermia therapy employs magnetic nanoparticles (MNPs) as heating medium under external alternating magnetic field. Among various MNPs, ferrite nanoparticles (FNPs) have gained significant attention for hyperthermia therapy due to their exceptional magnetic properties, high stability, favorable biological compatibility, and low toxicity. The utilization of FNPs holds immense potential for enhancing the effectiveness of hyperthermia therapy. The main hurdle for hyperthermia treatment includes optimizing the heat generation capacity of FNPs and controlling the local temperature of tumor region. This review aims to comprehensively evaluate the magnetic hyperthermia treatment (MHT) of FNPs, which is accomplished by elucidating the underlying mechanism of heat generation and identifying influential factors. Based upon fundamental understanding of hyperthermia of FNPs, valuable insights will be provided for developing efficient nanoplatforms with enhanced accuracy and magnetothermal properties. Additionally, we will also survey current research focuses on modulating FNPs' properties, external conditions for MHT, novel technical methods, and recent clinical findings. Finally, current challenges in MHT with FNPs will be discussed while prospecting future directions. Copyright © 2024 Elsevier B.V. All rights reserved. DOI: 10.1016/j.colsurfb.2024.113754 PMID: 38241891 [Indexed for MEDLINE] Conflict of interest statement: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
实验设计与方法 (Experimental Design & Methods)
采用差示扫描量热法、圆二色谱和荧光光谱等技术，系统测定蛋白质热变性温度和折叠稳定性。通过突变体分析探讨关键氨基酸残基的作用。
实验结果 (Experimental Results)
确定了蛋白质的关键热稳定区域，突变导致熔解温度变化15-25°C，为蛋白质工程改造提供了理论基础。
数据汇总 (Data Summary)
确定了蛋白质的关键热稳定区域，突变导致熔解温度变化15-25°C，为蛋白质工程改造提供了理论基础。
结论 (Conclusions)
热稳定性机制研究为改良蛋白质性能提供了重要参考。
实践意义 (Practical Significance)
对工业酶开发和蛋白质药物设计具有指导意义。