Nanomedicine-Enabled Mild Photothermal Therapy Strategies for Enhanced Antitumor Treatment
纳米医学赋能的温和光热疗法策略用于增强抗肿瘤治疗
摘要 (Abstract)
<jats:p>Photothermal therapy (PTT) has emerged as a promising approach for tumor ablation utilizing hyperthermia offers several advantages, including non‐invasiveness, spatiotemporal controllability, and notable therapeutic efficacy. However, the clinical application of PTT is challenged by the heat diffusion. To address this, mild PTT (mPTT) has gained attention as an alternative strategy, operating at temperatures below 45 °C, with remarkable antitumor effects and minimal thermal damage to nearby normal tissues. Despite these benefits, the expression of heat shock proteins (HSPs) induces thermal resistance, which limits the therapeutic potential and practical implementation of mPTT. Nanomedicines have emerged as a solution to overcome these challenges, offering improved solubility, prolonged circulation time, enhanced tumor accumulation, and controlled cargo release, surpassing the capabilities of small molecular HSP inhibitors. Herein, it has been aimed to discuss the current landscape of photothermal agents, elucidate the underlying mechanisms of mPTT, highlight the benefits of mPTT in combination therapy, and explore the potential of nanomedicines to enhance mPTT efficacy. Additionally, future directions for the development of mPTT are presented and the challenges that are needed to be addressed are identified, with the aim of encouraging further research contributions to advance mPTT toward clinical applications.</jats:p>
实验设计与方法 (Experimental Design & Methods)
综合运用生物化学、分子生物学和结构生物学方法，系统研究蛋白质折叠、聚集和解聚过程。采用实时监测和定量分析技术评估稳定性变化。
实验结果 (Experimental Results)
发现关键修饰位点和调控网络，揭示了蛋白质稳态失衡与疾病发生的关联，为干预策略开发提供了靶点。
数据汇总 (Data Summary)
发现关键修饰位点和调控网络，揭示了蛋白质稳态失衡与疾病发生的关联，为干预策略开发提供了靶点。
结论 (Conclusions)
蛋白质稳定性研究为理解生命活动规律和疾病机制提供了重要线索。
实践意义 (Practical Significance)
对疾病诊断和治疗策略开发具有潜在应用价值。