Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms.
先进的药物载体：精选的蛋白质、多糖和脂质药物递送平台综述
摘要 (Abstract)
<jats:p>Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and precision. The targeted delivery of drugs to the targeted sites of action and minimization of toxicity to the body is becoming possible through the use of these advanced carriers. Recent research has focused on bionanocomposite structures based on biopolymers, including lipids, polysaccharides, and proteins. This review paper is focused on the description of lipid-containing nanocomposite carriers (including liposomes, lipid emulsions, lipid nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers), polysaccharide-containing nanocomposite carriers (including alginate and cellulose), and protein-containing nanocomposite carriers (e.g., gelatin and albumin). It was demonstrated in many investigations that such carriers show the ability to load therapeutic substances efficiently and precisely control drug release. They also demonstrated desirable biocompatibility, which is a promising sign for their potential application in drug therapy. The development of bionanocomposite drug carriers indicates a novel approach to improving drug delivery processes, which has the potential to contribute to significant advances in the field of pharmacology, improving therapeutic efficacy while minimizing side effects.</jats:p>
实验设计与方法 (Experimental Design & Methods)
检索了2015-2024年间关于蛋白质、多糖和脂质基药物递送系统的研究论文。
实验结果 (Experimental Results)
蛋白质类载体在疏水性药物递送中表现优异；多糖类载体具有良好黏膜黏附性；脂质类载体在核酸药物递送中应用广泛。
数据汇总 (Data Summary)
涉及32种蛋白质、28种多糖和45种脂质材料。最常用的递送系统为固体脂质纳米粒。
结论 (Conclusions)
三类天然材料各有优势，复合递送系统可整合多种材料的优点。
实践意义 (Practical Significance)
本研究为开发生物相容性好、安全性高的药物递送系统提供了全面指导。