Agent useful as cosmetic or quasi-drug for scavenging active oxygen, inhibiting protein glycation, protein carbonylation and protein nitration, decomposing advanced glycation end products, and performing carbonylated proteolysis or nitrated proteolysis, comprises extract of Plinia cauliflora
作为化妆品或准药物的有效成分，用于清除活性氧、抑制蛋白质糖基化、蛋白质羰基化和蛋白质硝化、分解晚期糖基化终产物，并进行羰基化蛋白水解或硝化蛋白水解，包括巴西假叶海棠提取物
摘要 (Abstract)
1. Surg Neurol Int. 2026 Apr 24;17:246. doi: 10.25259/SNI_1191_2025. eCollection 2026. Surgical management of an intraluminal thrombus in the external jugular vein: A case report with near-infrared visualization as a useful adjunct. Chihara H(1), Maki Y(2), Agawa Y(3), Hatano T(3). Author information: (1)Department of Neurosurgery, Kyoto University, Kyoto, Japan. (2)Department of Neurosurgery, Hikone Chuo Hospital, Hikone, Japan. (3)Department of Neurosurgery, Kokura Memorial Hospital, Fukuoka, Japan. BACKGROUND: Surgical removal of a mass in the external jugular vein requires precise localization to ensure optimal cosmetic outcomes. While preoperative imaging is standard, intraoperative anatomical shifts can occur. We report a case where a near-infrared vein visualization device was used as a supplementary tool during the excision of an intraluminal thrombus. CASE DESCRIPTION: A 50-year-old woman presented, complaining of a subcutaneous mass in the left neck. She used a sports bra for the previous 6 weeks to participate in a marathon race. Ultrasonography revealed an intraluminal mass arising from the venous wall of the left external jugular vein. This finding suggested that the mass could be a thrombus. An anticoagulant agent was initiated. However, the lesion was resistant to treatment and continued increasing. Therefore, we planned surgical removal of the subcutaneous mass. Before the design of a skin incision, we identified the subcutaneous mass using a near-infrared visualization device. The mass was accurately localized and dissected through a minimal 2-cm transverse skin incision. Pathological diagnosis was the combination of intravenous pyogenic granuloma and organized thrombus. There was no recurrence of the mass at the final follow-up of 2 years after surgery. CONCLUSION: We describe the successful removal of an intraluminal thrombus in the external jugular vein. Near-infrared vein visualization was found to be a useful adjunct in our experience. Copyright: © 2026 Surgical Neurology International. DOI: 10.25259/SNI_1191_2025 PMCID: PMC13157943 PMID: 42116896 Conflict of interest statement: There are no conflicts of interest.
实验设计与方法 (Experimental Design & Methods)
采用结构生物学、计算机模拟和实验验证相结合的方法，系统分析蛋白质结构和功能关系。通过分子对接、动力学模拟等技术预测药物-靶点相互作用。
实验结果 (Experimental Results)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
数据汇总 (Data Summary)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
结论 (Conclusions)
基于蛋白质的药物研发策略为创新药物开发提供了新方向。
实践意义 (Practical Significance)
对推动靶向药物研发和精准医疗发展具有重要科学价值。