Application of protein/polysaccharide aerogels in drug delivery system: A review
蛋白质/多糖气凝胶在药物递送系统中的应用：综述
摘要 (Abstract)
1. Int J Biol Macromol. 2023 Aug 30;247:125727. doi: 10.1016/j.ijbiomac.2023.125727. Epub 2023 Jul 8. Application of protein/polysaccharide aerogels in drug delivery system: A review. Zhu Y(1), Li H(2), Peng C(3), Ma J(4), Huang S(4), Wang R(4), Wu B(5), Xiong Q(6), Peng D(7), Huang S(8), Chen J(9). Author information: (1)Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, PR China; National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. (2)Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, PR China. (3)School of Pharmacy, Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Anhui University of Chinese Medicine, Hefei 230012, PR China. (4)Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, PR China. (5)National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. (6)Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, PR China; Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai'an 223003, PR China. Electronic address: qpxiong@gmail.com. (7)School of Pharmacy, Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Anhui University of Chinese Medicine, Hefei 230012, PR China. Electronic address: pengdy@ahtcm.edu.cn. (8)National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: huangnn421@163.com. (9)Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, PR China. Electronic address: chenjing6910@163.com. Drug delivery systems have emerged as a prominent research focus in the field of drug development, offering enhanced stability and improved bioavailability. Among them, protein (silk, gelatin and whey) or polysaccharide (alginate, chitosan, cellulose, starch, pectin and carrageenan) aerogels derived from natural sources have gained increasing popularity due to their unique advantages, such as cost-effectiveness, flexible preparation, bioactivity, biocompatibility, and biodegradability. However, despite their growing significance, there remains a lack of comprehensive information and ongoing confusion regarding the application of protein/polysaccharide aerogels in drug delivery system. Hence, the objective of this review was to provide a comprehensive review of the research progress in protein/polysaccharide aerogels for drug delivery systems from the perspective of aerogels category, synthesis strategy, drug-loading method, performance characteristic and release mechanism. Furthermore, by consolidating the existing information, we aimed to present our own perspectives and insights on the future development of protein/polysaccharide aerogels in drug delivery system. In conclusion, this comprehensive review served as a valuable resource for researchers and scholars, addressing the current gaps in knowledge and clarifying the complex landscape of protein/polysaccharide aerogels in drug delivery system. Copyright © 2023. Published by Elsevier B.V. DOI: 10.1016/j.ijbiomac.2023.125727 PMID: 37429347 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
研究方法综述 (Methods Overview)
采用结构生物学、计算机模拟和实验验证相结合的方法，系统分析蛋白质结构和功能关系。通过分子对接、动力学模拟等技术预测药物-靶点相互作用。
数据总结 (Data Summary)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
主要发现 (Key Findings)
基于结构设计的小分子抑制剂活性提高10倍以上，成功解析了多个重要蛋白质的三维结构，为药物设计提供了结构基础。
结论 (Conclusions)
基于蛋白质的药物研发策略为创新药物开发提供了新方向。
实践意义 (Practical Significance)
对推动靶向药物研发和精准医疗发展具有重要科学价值。