Protein corona, influence on drug delivery system and its improvement strategy: A review.
蛋白冠对药物递送系统的影响及其改进策略：综述
📄 英文摘要 English Abstract
Nano drug delivery systems offer several benefits, including enhancing drug solubility, regulating drug release, prolonging drug circulation time, and minimized toxicity and side effects. However, upon entering the bloodstream, nanoparticles (NPs) encounter a complex biological environment and get absorbed by various biological components, primarily proteins, leading to the formation of a 'Protein Corona'. The formation of the protein corona is affected by the characteristics of NPs, the physiological environment, and experimental design, which in turn affects of the immunotoxicity, specific recognition, cell uptake, and drug release of NPs. To improve the abundance of a specific protein on NPs, researchers have explored pre-coating, modifying, or wrapping NPs with the cell membrane to reduce protein adsorption. This paper, we have reviewed studies of the protein corona in recent years, summarized the formation and detection methods of the protein corona, the effect of the protein corona composition on the fate of NPs, and the design of new drug delivery systems based on the optimization of protein corona to provide a reference for further study of the protein corona and a theoretical basis for the clinical transformation of NPs.
📄 中文摘要 Chinese Abstract
📋 英文结构化总结 English Structured Summary
摘要整理
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Background: Nano drug delivery systems offer several benefits, including enhancing drug solubility, regulating drug release, prolonging drug circulation time, and minimized toxicity and side effects. However, upon entering the bloodstream, nanoparticles (NPs) encounter a complex biological environment and get absorbed by various biological components, primarily proteins, leading to the formation of a 'Protein Corona'. The formation of the protein corona is affected by the characteristics of NPs, the physiological environment, and experimental design, which in turn affects of the immunotoxicity, specific recognition, cell uptake, and drug release of NPs.
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Methods: N/A - Review article
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Results: The formation of the protein corona is affected by the characteristics of NPs, the physiological environment, and experimental design, which in turn affects of the immunotoxicity, specific recognition, cell uptake, and drug release of NPs. To improve the abundance of a specific protein on NPs, researchers have explored pre-coating, modifying, or wrapping NPs with the cell membrane to reduce protein adsorption.
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Data Summary: No quantitative results or key statistics are provided in the extracted text.
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Conclusions: This paper, we have reviewed studies of the protein corona in recent years, summarized the formation and detection methods of the protein corona, the effect of the protein corona composition on the fate of NPs, and the design of new drug delivery systems based on the optimization of protein corona to provide a reference for further study of the protein corona and a theoretical basis for the clinical transformation of NPs.
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Practical Significance: The design of new drug delivery systems based on the optimization of protein corona to provide a reference for further study of the protein corona and a theoretical basis for the clinical transformation of NPs.
📋 中文结构化总结 Chinese Structured Summary
背景:
纳米药物递送系统具有诸多优势，包括提高药物溶解度、调控药物释放、延长药物循环时间以及降低毒性和副作用。然而，纳米颗粒（NPs）进入血液循环后会遇到复杂的生物环境，并被各种生物成分（主要是蛋白质）吸附，从而形成"蛋白质冠"。蛋白质冠的形成受纳米颗粒特性、生理环境和实验设计的影响，进而影响纳米颗粒的免疫毒性、特异性识别、细胞摄取和药物释放。
方法:
不适用——综述类文章
结果:
蛋白质冠的形成受纳米颗粒特性、生理环境和实验设计的影响，进而影响纳米颗粒的免疫毒性、特异性识别、细胞摄取和药物释放。为了提高纳米颗粒表面特定蛋白的丰度，研究人员探索了预涂层、修饰或用细胞膜包裹纳米颗粒以减少蛋白质吸附的方法。
数据摘要:
所提取的文本中未提供定量结果或关键统计数据。
结论:
本文综述了近年来蛋白质冠的相关研究，总结了蛋白质冠的形成与检测方法、蛋白质冠组成对纳米颗粒命运的影响，以及基于蛋白质冠优化的新型药物递送系统的设计，旨在为进一步研究蛋白质冠提供参考，并为纳米颗粒的临床转化提供理论基础。
实际意义:
基于蛋白质冠优化的新型药物递送系统的设计，为进一步研究蛋白质冠提供参考，并为纳米颗粒的临床转化提供理论基础。