化学药物制剂

PROTACs in targeted protein degradation: Advances in development and AI-enhanced drug discovery

Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy

Pen-866, a miniature drug conjugate of a heat shock protein 90 (HSP90) ligand linked to SN38 for patients with advanced solid malignancies: Phase I and expansion cohort results.

Membrane Proteins as Targets for Biological Drugs

Medicinal Research Reviews

A Review on the Novel Coronavirus Disease based on In-silico Analysis of Various Drugs and Target Proteins

Interaction of Platinum-based Drugs with Proteins: An Overview of Representative Crystallographic Studies

The Right Tool for the Job: An Overview of Hsp90 Inhibitors.

Therapeutic Drug Monitoring of Targeted Anticancer Protein Kinase Inhibitors in Routine Clinical Use: A Critical Review

The Right Tool for the Job: An Overview of Hsp90 Inhibitors.

CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins

Recent advances in the determination of unbound concentration and plasma protein binding of drugs: Analytical methods.

New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights

Recent advances in identifying protein targets in drug discovery.

鉴定小分子药物的靶蛋白对于理解药物的作用机理以及药物副作用至关重要。传统方法需要对药物进行化学修饰共价交联，可能会导致药物活性的改变。目前已经发展多种无需化学修饰便可以对药物靶蛋白鉴定的方法，包括药物亲和力反应靶标稳定性技术 (Drug affinity responsive target stability，DARTS)、蛋白质氧化速率稳定性技术 (Stability of proteins from rates of oxidation，SPROX)、细胞热移位分析...

[Identification techniques of small molecule drug target proteins without chemical modification and its applications: a review].

Latest trends in structure based drug design with protein targets.

Role of protein-protein interactions in allosteric drug design for DNA methyltransferases.

Protein-protein complexes as targets for drug discovery against infectious diseases.

Chagas disease is a serious parasitic infection caused by Trypanosoma cruzi. Unfortunately, the current chemotherapeutic tools are not enough to combat the infection. The aim of this study was to evaluate the trypanocidal activity of ben...